Thiago Carvalho on Nostr: 'Langerhans cell Histiocytosis (LCH) and Erdheim-Chester disease (ECD) are clonal ...
'Langerhans cell Histiocytosis (LCH) and Erdheim-Chester disease (ECD) are clonal myeloid disorders, associated with MAP-Kinase activating mutations and an increased risk of neurodegeneration. Surprisingly, we found pervasive PU.1+ microglia mutant clones across the brain of LCH and ECD patients with and without neurological symptoms, associated with microgliosis, reactive astrocytosis, and neuronal loss.'
#Preprint
https://www.biorxiv.org/content/10.1101/2024.07.30.605867v1Published at
2024-08-01 08:57:07Event JSON
{
"id": "2ae9efcccdb5653ff61bfe3c511fe248bd0444216eb3e218a521fd690c80c76d",
"pubkey": "376d961fc946cb96839a4d257809dc9e6d237e2d0cc158199b8cc5c5771939a6",
"created_at": 1722502627,
"kind": 1,
"tags": [
[
"t",
"preprint"
],
[
"proxy",
"https://qoto.org/users/cyrilpedia/statuses/112885932183861601",
"activitypub"
]
],
"content": "'Langerhans cell Histiocytosis (LCH) and Erdheim-Chester disease (ECD) are clonal myeloid disorders, associated with MAP-Kinase activating mutations and an increased risk of neurodegeneration. Surprisingly, we found pervasive PU.1+ microglia mutant clones across the brain of LCH and ECD patients with and without neurological symptoms, associated with microgliosis, reactive astrocytosis, and neuronal loss.'\n#Preprint \nhttps://www.biorxiv.org/content/10.1101/2024.07.30.605867v1",
"sig": "eba3992197f57b7ba328d52022f098e961c5d6f34a9952245ea1919c19455839a0cd2f8f4d323f917a10118fd2f03dc68fbafba104688c8ee3e3511c8cb1a683"
}
