npub19f…grfww on Nostr: https://www.nature.com/articles/s41586-023-06800-3 "N1-methylpseudouridylation of ...
https://www.nature.com/articles/s41586-023-06800-3
"N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting"
TL;DR
The psuedouridine that won those dorks the nobel and keep mRNA intact long enough to do the nasty is fundamentally flawed.
It's missing some teeth on a cog and the gearbox slips 1/4 of the time. Causing 1/4 of cells affected by it to produce RANDOM proteins.
The sink isn't going to snuck in overnight but it pulls the rug under Moderna's entire platform. They're toast.
"N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting"
TL;DR
The psuedouridine that won those dorks the nobel and keep mRNA intact long enough to do the nasty is fundamentally flawed.
It's missing some teeth on a cog and the gearbox slips 1/4 of the time. Causing 1/4 of cells affected by it to produce RANDOM proteins.
The sink isn't going to snuck in overnight but it pulls the rug under Moderna's entire platform. They're toast.