Erin on Nostr: Front Pharmacol. 2023 May 12;14:1192022. doi: 10.3389/fphar.2023.1192022 According to ...
Front Pharmacol. 2023 May 12;14:1192022. doi: 10.3389/fphar.2023.1192022
According to the current hypothetical model, FFA enhances GABAergic signaling via activity at serotonin (5-hydroxytryptophan, 5-HT) receptors and inhibits excitatory signaling through sigma-1 (σ1)-mediated mechanisms, thereby restoring the balance between inhibition and excitation (Sourbron et al., 2017; Martin et al., 2020; Sourbron and Lagae, 2022). Nonetheless, other mechanisms are likely to be involved. Recent data suggest that FFA confers clinical benefit beyond seizure reduction alone (Jensen et al., 2022; Jensen et al., 2023),
According to the current hypothetical model AND other mechanisms are likely to be involved? What could possibly go wrong?
According to the current hypothetical model, FFA enhances GABAergic signaling via activity at serotonin (5-hydroxytryptophan, 5-HT) receptors and inhibits excitatory signaling through sigma-1 (σ1)-mediated mechanisms, thereby restoring the balance between inhibition and excitation (Sourbron et al., 2017; Martin et al., 2020; Sourbron and Lagae, 2022). Nonetheless, other mechanisms are likely to be involved. Recent data suggest that FFA confers clinical benefit beyond seizure reduction alone (Jensen et al., 2022; Jensen et al., 2023),
According to the current hypothetical model AND other mechanisms are likely to be involved? What could possibly go wrong?