Study Finds on Nostr: 'Mini-brains' reveal genetic mutation linked to dementia and other diseases ...
'Mini-brains' reveal genetic mutation linked to dementia and other diseases
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Scientists at the University of Bath have used lab-made 'mini-brains' to study a gene called Angiogenin (ANG) that is implicated in neurodegenerative diseases such as frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), and Parkinson's disease. The researchers found that the mutated form of the gene causes stem cells to persist in their original state for longer than they should, resulting in neurodevelopmental defects in nerve cells. The study suggests that defects occurring during early development may prime nerve-cell degeneration. The researchers hope that their findings will lead to new detection methods and treatments for these diseases. The study was funded by the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), BRACE, and the Wellcome Trust VIP award.
#Mini-brains #GeneticMutation #Dementia #NeurodegenerativeDiseases #Angiogenin #FrontotemporalDementia #AmyotrophicLateralSclerosis #Parkinson'sDisease
https://studyfinds.org/mini-brains-mutation-dementia/
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Scientists at the University of Bath have used lab-made 'mini-brains' to study a gene called Angiogenin (ANG) that is implicated in neurodegenerative diseases such as frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), and Parkinson's disease. The researchers found that the mutated form of the gene causes stem cells to persist in their original state for longer than they should, resulting in neurodevelopmental defects in nerve cells. The study suggests that defects occurring during early development may prime nerve-cell degeneration. The researchers hope that their findings will lead to new detection methods and treatments for these diseases. The study was funded by the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), BRACE, and the Wellcome Trust VIP award.
#Mini-brains #GeneticMutation #Dementia #NeurodegenerativeDiseases #Angiogenin #FrontotemporalDementia #AmyotrophicLateralSclerosis #Parkinson'sDisease
https://studyfinds.org/mini-brains-mutation-dementia/