Mike Malaska on Nostr: Former medicinal chemist here. Developing drugs is really hard. We have a 96% failure ...

Former medicinal chemist here.

Developing drugs is really hard. We have a 96% failure rate.

Here is some math.
Assume $300K FTE rate per scientist.

Find a preclinical candidate: $15M
Tox testing: $5M

Phase 1 clinical trials (safety in healthy subjects - is it safe?): $50M

Phase 2 clinical trails (efficacy in diseased subjects - does it work?): $250M

Phase 3 clinical trials (liability): $300M

Total: $620M if everything works.

But, 96% failure rate.