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2025-01-13 18:51:37

whygetfat on Nostr: Max Gulhane, MD: "A couple of points about potentially using cold as treatment in ...

Max Gulhane, MD: "A couple of points about potentially using cold as treatment in something like prostate cancer. I see patients, and the patients are coming in and some of them are on androgen deprivation therapy. (For the listeners, it's an adjunctive method of treating prostate cancer that involves essentially turning off the male hormonal axis in an effort to prevent growth of testosterone-sensitive, potentially malignant prostate cells.) The issue here is that this essentially induces menopause-like symptoms in men, with the hot flashes and all this kind of thing. That's instructive for a number of reasons.
"One, it's potentially suggesting that menopause in women is a testosterone deficiency process. Two, I think it's like bludgeoning it with a hammer. If we could have a way more careful and physiological process that could potentially reduce the PSA, reduce the proliferation of malignant cells and keep the testosterone high, then that would be amazing."
Thomas Seager, PhD: "[…] The hypothesis is that because testosterone is anabolic, that it might promote the growth of these malignant cancer cells, because it promotes growth generally. So some physician has it in his head that we need to suppress testosterone, and that will somehow slow down the growth of prostate cancer tumor. This is dead wrong.
"It's Abraham Morgentaler, who is a physician and researcher in the United States, and he examined the data. These are large epidemiological and clinical studies. He says high testosterone is not associated with increased risk of prostate [cancer]. High testosterone protects against prostate cancer. It is exactly the opposite.
"One of the friends that I talked to when I had my high PSA, 'cause I called a bunch of guys. It wasn't easy. I'm like, 'You know, I just got these labs back. Scott, have you ever had your PSA checked?'
"Everybody had their PSA checked and everybody told me a different story. One of them was, he had a prostatectomy. He will suffer erectile dysfunction the rest of his life. He's resigned to this. He had a super-sensitive scan that showed cell that might be, maybe, cancerous, that maybe didn't get removed. And as a precautionary measure, his high-tech physician put him on testosterone blockers. He felt terrible. He gained weight. Of course his metabolism was wrecked, his muscle tone was wrecked.
"But in his mind, just like I was when I got my elevated PSA, he was scared. He said, 'I got to do this for my family. I got to do everything I can do to try and stay alive.' But his physician was harming him because the guy didn't know. The physician hasn't read the research. He's doing whatever they taught him in medical school without updating that based upon the real data.
"You can download Abraham Morgentaler papers on this. I've cited them. I put it up on our website. I've cited them in my book. You can listen to Brigham Buhler on this, he was really good at explaining the research. Morgentaler himself I think is on Instagram and trying to get the word out that testosterone suppression is hurting men's prostate health rather than helping it."
Thomas Seager, PhD with Dr Max Gulhane @ 16:22–20:32 https://youtu.be/5D6vVDvvRFA&t=982
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