Edward Nirenberg on Nostr: I do not feel that controlled human infection models (CHIMs) can suffice as a ...
I do not feel that controlled human infection models (CHIMs) can suffice as a replacement for Phase 3 studies altogether. I think they have to be supported by a large safety and immunogenicity study which perhaps considers incidence of pertussis as a secondary endpoint.
5/5
Published at
2024-09-20 17:10:24Event JSON
{
"id": "ed6abbd603692c9f820e257f71c882fc8c1a90234fb7ec8b9d2f5b2c4e4f0af5",
"pubkey": "c67b38e4c5023e985f04ae7ab6a6669cf463220e1b9ed54b897d1957004603a4",
"created_at": 1726852224,
"kind": 1,
"tags": [
[
"e",
"7f836d5611b5ab75e9492a203695a7c055b466a948b18ffb7761880d03dd1f1d",
"wss://relay.mostr.pub",
"reply"
],
[
"proxy",
"https://med-mastodon.com/users/enirenberg/statuses/113170987356217409",
"activitypub"
]
],
"content": "I do not feel that controlled human infection models (CHIMs) can suffice as a replacement for Phase 3 studies altogether. I think they have to be supported by a large safety and immunogenicity study which perhaps considers incidence of pertussis as a secondary endpoint.\n5/5",
"sig": "72ae88a4edb486afc34072b0e1326f0a6071b01773229eca97837769f0ac8e50a8e80a78940a47d00ca43f6d7034c3f921e7f5576b69fb3de0f28333d69f6c9e"
}
