Jonathan Kamens on Nostr: Because this trial involves a live, attenuated cholera vaccine, an important measure ...

Because this trial involves a live, attenuated cholera vaccine, an important measure of success is, does the vaccine multiply and take up residence in the intestines of trial subjects?
This is important both because the bacteria need to multiply to give the immune system something to resist, and because one reasons this vaccine immunizes quickly is that once it populates the gut, it prevents "real" (unattenuated) cholera bacteria from doing so.
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