Michael Emerman on Nostr: A trio of interesting papers about early steps of HIV-1 infection online last week. ...

A trio of interesting papers about early steps of HIV-1 infection online last week. The Vinay Pathak lab show that uncoating of the virion requires the synthesis of long reverse transcriptase products https://www.science.org/doi/full/10.1126/sciadv.adn7033. The Jarrod Johnson group show that this slow uncoating step protects the viral nucleic acid from sensing by cGAS https://www.biorxiv.org/content/10.1101/2024.04.22.590513v2.abstract.