PLOS Biology on Nostr: Previous #cryoEM of #synucleinopathy α-synuclein fibrils revealed a ‘mystery ...
Previous #cryoEM of #synucleinopathy α-synuclein fibrils revealed a ‘mystery density’ at the protofilament core. @jakob_lab &co now show that it's #polyphosphate, which binds a lysine-rich pocket & helps stabilize the fiber #ParkinsonsDisease #PLOSBiology
https://plos.io/3YP7Gdf 
Published at
2024-11-01 09:52:11Event JSON
{
"id": "b4c47ffe492208b5305c1efa01f5627573a301017152b0452692450b02c57f7a",
"pubkey": "3e45c31cdfbf1f386c345672cbc9f1be2abe7931c240e997d0f909a0d14244c8",
"created_at": 1730454731,
"kind": 1,
"tags": [
[
"t",
"CryoEM"
],
[
"t",
"synucleinopathy"
],
[
"t",
"polyphosphate"
],
[
"t",
"parkinsonsdisease"
],
[
"t",
"plosbiology"
],
[
"proxy",
"https://fediscience.org/users/PLOSBiology/statuses/113407081311733778",
"activitypub"
]
],
"content": "Previous #cryoEM of #synucleinopathy α-synuclein fibrils revealed a ‘mystery density’ at the protofilament core. @jakob_lab \u0026co now show that it's #polyphosphate, which binds a lysine-rich pocket \u0026 helps stabilize the fiber #ParkinsonsDisease #PLOSBiology https://plos.io/3YP7Gdf\n\nhttps://fediscience.org/system/media_attachments/files/113/407/081/154/939/632/original/301e9bfeae3411cf.jpg",
"sig": "9446bef4db3624fe14063d9c94940b075ef4d44c3f1c091c9f26413edb27b948c2243ab42c8e6c04c468a99cbd936ab92fd27800bbb41ee2a722e80dd54c1eb3"
}
