Brian Vastag on Nostr: Listened to 4 hours of the NIH meeting to discuss upcoming initiative for clinical ...
Listened to 4 hours of the NIH meeting to discuss upcoming initiative for clinical trials for #longcovid.
Some themes
- Several people advocated small, fast trials to ID subsets who benefit from drugs & find meaningful clinical endpoints.
Viral persistence, immune dysfunction & microclots all offer targets for treatment but not every patient shows each feature; makes trial design tricky and requires work to ID eligible patients.
- Big PhRMA still largely on the sidelines
Some themes
- Several people advocated small, fast trials to ID subsets who benefit from drugs & find meaningful clinical endpoints.
Viral persistence, immune dysfunction & microclots all offer targets for treatment but not every patient shows each feature; makes trial design tricky and requires work to ID eligible patients.
- Big PhRMA still largely on the sidelines