Chapulín Enojado on Nostr: npub1psdfx…99sr7 As one of my professors said, "There's no such thing as a 'pure' ...
npub1psdfxfpxz2cwmmnsk60y3nqpn2tqh9n24h4hstvfkwvr6eaek9js499sr7 (npub1psd…9sr7)
As one of my professors said, "There's no such thing as a 'pure' agonist or antagonist. They all have side-effects." The brain-gut axis is complicated, and modulating GLP-1 influences all sorts of reward-related behaviors. Different GLP-1R agonists have different "side" effects, and some GLP-1R agonists may even be useful in bipolar disorder (see below). So maybe they have other effects on motivation, attention, focus? Appetite and satiety are only the most popular indications (for now) because someone found a drug that sells. It's clear, though, that modulating GLP-1 produces many other effects.
https://pubmed.ncbi.nlm.nih.gov/31954756/
As one of my professors said, "There's no such thing as a 'pure' agonist or antagonist. They all have side-effects." The brain-gut axis is complicated, and modulating GLP-1 influences all sorts of reward-related behaviors. Different GLP-1R agonists have different "side" effects, and some GLP-1R agonists may even be useful in bipolar disorder (see below). So maybe they have other effects on motivation, attention, focus? Appetite and satiety are only the most popular indications (for now) because someone found a drug that sells. It's clear, though, that modulating GLP-1 produces many other effects.
https://pubmed.ncbi.nlm.nih.gov/31954756/