spore on Nostr: Always nice to discuss these topics. About the amyloidosis patients, they used to be ...
Always nice to discuss these topics.
About the amyloidosis patients, they used to be terminal patients, but with partisiran they are not terminal anymore!
They are taking LNPs every 2 weeks for the rest of their lives, the oldest of them since 2015 (
https://clinicaltrials.gov/ct2/show/NCT02510261 - it took 3 years more to approve it). So it's not a single shot once in a while, it's a very suitable cohort to test chronic exposition to those molecules. Under that clear evidence and weighting the risks and benefits of its mass administration, the decision was made.
My point is, where is the new evidence (after 2018) that supports all the conspiracy theories going around?
(Just as a note apart, testing exact molecular compounds for decades before approving them is just unrealistic, that's why phase 3 and phase 4 was delineated...
Another note: on clinical trials, terminal patient = ok give whatever, is an over simplification of how the real process is going on. Terminal patients are still humans, they are on a very vulnerable position and there are still many regulations that must be met, this is more of a bioethics topic...)
Published at
2023-03-14 13:24:05Event JSON
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"content": "\nAlways nice to discuss these topics. \n\nAbout the amyloidosis patients, they used to be terminal patients, but with partisiran they are not terminal anymore!\nThey are taking LNPs every 2 weeks for the rest of their lives, the oldest of them since 2015 (https://clinicaltrials.gov/ct2/show/NCT02510261 - it took 3 years more to approve it). So it's not a single shot once in a while, it's a very suitable cohort to test chronic exposition to those molecules. Under that clear evidence and weighting the risks and benefits of its mass administration, the decision was made.\nMy point is, where is the new evidence (after 2018) that supports all the conspiracy theories going around?\n\n(Just as a note apart, testing exact molecular compounds for decades before approving them is just unrealistic, that's why phase 3 and phase 4 was delineated...\n\nAnother note: on clinical trials, terminal patient = ok give whatever, is an over simplification of how the real process is going on. Terminal patients are still humans, they are on a very vulnerable position and there are still many regulations that must be met, this is more of a bioethics topic...)\n\n\n",
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