Thiago Carvalho on Nostr: 'We demonstrate the first generalizable strategy using a small molecule to ...
'We demonstrate the first generalizable strategy using a small molecule to selectively kill TP53 mutant cells. This molecule binds the Y220C mutant of p53 and concentrates a PLK1 inhibitor in cells harboring TP53 Y220C mutations.'
#Preprint
https://www.biorxiv.org/content/10.1101/2024.07.27.605429v1Published at
2024-07-29 11:37:58Event JSON
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"content": "'We demonstrate the first generalizable strategy using a small molecule to selectively kill TP53 mutant cells. This molecule binds the Y220C mutant of p53 and concentrates a PLK1 inhibitor in cells harboring TP53 Y220C mutations.'\n#Preprint\nhttps://www.biorxiv.org/content/10.1101/2024.07.27.605429v1",
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