Cian O’Donnell on Nostr: Synapses fluctuate in size over days-weeks (example data in pic below). Why? We used ...

Synapses fluctuate in size over days-weeks (example data in pic below). Why?

We used math and computational modelling to ask if it could be explained by stochastic gene expression.

Turns out yes! And interestingly it induces
1. strong temporal correlations in protein fluctuations (days timescale)
2. Strong spatial correlations across synapses, due to dendritic mRNA count fluctuations.

If you're at #cosyne2024 check out postdoc Oleg Senkevich's poster 2-151 on this on Friday.