nature :press: on Nostr: A mechanism for hypoxia-induced inflammatory cell death in cancer Nature, Published ...
A mechanism for hypoxia-induced inflammatory cell death in cancer
Nature, Published online: 06 November 2024; doi:10.1038/s41586-024-08136-yWe find that PTP1B and ABL1/2 reciprocally control RNF213 tyrosine phosphorylation and its oligomerization and RZ domain activation, and identify a unique PTP1B–RNF213–CYLD–SPATA2 pathway critical for the control of inflammatory cell death in hypoxic tumours. #press
https://www.nature.com/articles/s41586-024-08136-y?utm_source=press.coop
Nature, Published online: 06 November 2024; doi:10.1038/s41586-024-08136-yWe find that PTP1B and ABL1/2 reciprocally control RNF213 tyrosine phosphorylation and its oligomerization and RZ domain activation, and identify a unique PTP1B–RNF213–CYLD–SPATA2 pathway critical for the control of inflammatory cell death in hypoxic tumours. #press
https://www.nature.com/articles/s41586-024-08136-y?utm_source=press.coop