Andrew Zonenberg on Nostr: Is there a general trend for how pharmacokinetics of lipid-soluble drugs are impacted ...

Is there a general trend for how pharmacokinetics of lipid-soluble drugs are impacted by abnormally high or low blood lipid levels? I assume there's at least *some* effect but I'm the wrong kind of doctor to have studied that :)

My intuition says that higher lipid levels will lead to improved bioavailability (more carrying capacity per unit volume of blood so more efficient absorption) and higher peak concentrations, and conversely for lower levels. But I have no idea what (if anything) it would do to things like elimination half life.